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N1162

Sigma-Aldrich

NS3763

≥98% (HPLC), solid

Synonym(s):

5-Carboxy-2,4-dibenzamidobenzoic acid

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About This Item

Empirical Formula (Hill Notation):
C22H16N2O6
CAS Number:
70553-45-6
Molecular Weight:
404.37
MDL number:
MFCD00334657
UNSPSC Code:
12352202
PubChem Substance ID:
24724545
NACRES:
NA.77

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: ~24 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1cc(C(O)=O)c(NC(=O)c2ccccc2)cc1NC(=O)c3ccccc3

InChI

1S/C22H16N2O6/c25-19(13-7-3-1-4-8-13)23-17-12-18(16(22(29)30)11-15(17)21(27)28)24-20(26)14-9-5-2-6-10-14/h1-12H,(H,23,25)(H,24,26)(H,27,28)(H,29,30)

InChI key

UUDYZUDTQPLDDP-UHFFFAOYSA-N

Biochem/physiol Actions

First non-competitive antagonist of GluK5 receptor.

Features and Benefits

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
025K4606

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Journal of cell science, 124(Pt 9), 1510-1518 (2011-04-20)
Autophagy is a lysosome-mediated self-degradation process of eukaryotic cells that, depending on the cellular milieu, can either promote survival or act as an alternative mechanism of programmed cell death (PCD) in terminally differentiated cells. Despite the important developmental and medical
Saravanapriah Nadarajan et al.
Development (Cambridge, England), 136(13), 2223-2234 (2009-06-09)
Fertility depends on germline stem cell proliferation, meiosis and gametogenesis, yet how these key transitions are coordinated is unclear. In C. elegans, we show that GLP-1/Notch signaling functions in the germline to modulate oocyte growth when sperm are available for
Katherine Waters et al.
Developmental biology, 344(2), 1011-1025 (2010-07-06)
Proliferating germ cells in Caenorhabditiselegans provide a useful model system for deciphering fundamental mechanisms underlying the balance between proliferation and differentiation. Using gene expression profiling, we identified approximately 200 genes upregulated in the proliferating germ cells of C. elegans. Functional
Peter E A Ash et al.
Human molecular genetics, 19(16), 3206-3218 (2010-06-10)
RNA-binding protein TDP-43 has been associated with multiple neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. We have engineered pan-neuronal expression of human TDP-43 protein in Caenorhabditis elegans, with the goal of generating a convenient in vivo model
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