M9191
Microsomes from Liver, Pooled
from rat(Sprague-Dawley), female
Synonym(s):
lab equipment accessory
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About This Item
UNSPSC Code:
12161501
NACRES:
NA.47
Recommended Products
biological source
rat (Sprague-Dawley)
Quality Level
form
liquid
specific activity
≥20 units/mg protein, pH 7.4, 37 °C
packaging
vial of ~10 mg
shipped in
dry ice
storage temp.
−70°C
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Biochem/physiol Actions
Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.
Unit Definition
One unit will reduce 1 nanomole of cytochrome C per minute at pH 7.4 at 37 deg C.
7-ethoxyresorufin O-deethylase activity: One unit will hydroxylate 1.0 picomole paclitaxel per minute at pH 7.4 at 37 deg C.
7-ethoxyresorufin O-deethylase activity: One unit will hydroxylate 1.0 picomole paclitaxel per minute at pH 7.4 at 37 deg C.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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