Skip to Content
Merck
All Photos(4)

Key Documents

H7509

Sigma-Aldrich

(Hydroxypropyl)methyl cellulose

viscosity 2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

Synonym(s):

2-Hydroxypropyl methyl cellulose ether

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352201
NACRES:
NA.25

biological source

plant

form

powder

mol wt

~86 kDa

color

white to off-white

viscosity

2,600-5,600 cP, 2 % in H2O(20 °C)(lit.)

solubility

water: 10 mg/mL, clear to very slightly hazy, colorless

storage temp.

room temp

Looking for similar products? Visit Product Comparison Guide

General description

(Hydroxypropyl)methylcellulose (HPMC) is a water-soluble polymer derived from cellulose. This polysaccharide forms colloids when dissolved in water. HPMC is a hydrocolloid produced artificially from natural substances. It consists of 28-30% methoxyl content and 7-12% of hydroxypropoxyl content.

Application

(Hydroxypropyl)methyl cellulose (HPMC) has been used:
  • as a viscosity modifier in the preparation of printable ink
  • as a viscosifier in the preparation of hydroxyapatite (HAP) suspension
  • in the preparation of HPMC gels and composite gels

Thickener for aqueous and non-aqueous systems, clear films with grease resistance, binders, lubricants, steric stabilizer and water retention aid.

Biochem/physiol Actions

(Hydroxypropyl)methylcelluloses (HPMCs) act as suspension aids, surfactants, lubricants, protective colloids, and emulsifiers. Additionally, solutions of these polymers show thermal gelation properties. They are generally used as binders, thickeners, film formers, and water retention agents. HPMC also elicits surface-active properties.

Features and Benefits

Dissolves in water, undergoes reversible gelation upon heating, non-ionic, does not complex with ionic species and is surface active and enzyme resistant. Solutions are pseudoplastic.

Other Notes

To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Jenny Högström et al.
Cancer research, 78(20), 5820-5832 (2018-08-30)
The homeobox transcription factor PROX1 is induced by high Wnt/β-catenin activity in intestinal adenomas and colorectal cancer, where it promotes tumor progression. Here we report that in LGR5+ colorectal cancer cells, PROX1 suppresses the Notch pathway, which is essential for
Alexandre Goyon et al.
Electrophoresis, 39(16), 2083-2090 (2018-05-19)
The determination of mAb critical quality attributes (CQA) is crucial for their successful application in health diseases. A generic CZE method was developed for the high-resolution separation of various mAb charge variants, which are often recognized as important CQA. A
Bernd Moritz et al.
Electrophoresis, 38(24), 3136-3146 (2017-09-10)
CZE is a well-established technique for charge heterogeneity testing of biopharmaceuticals. It is based on the differences between the ratios of net charge and hydrodynamic radius. In an extensive intercompany study, it was recently shown that CZE is very robust
Mylène Tajan et al.
Nature communications, 12(1), 366-366 (2021-01-16)
Many tumour cells show dependence on exogenous serine and dietary serine and glycine starvation can inhibit the growth of these cancers and extend survival in mice. However, numerous mechanisms promote resistance to this therapeutic approach, including enhanced expression of the de
Francis W Hunter et al.
Biochemical pharmacology, 89(2), 224-235 (2014-03-19)
The nitro-chloromethylbenzindoline prodrug SN29428 has been rationally designed to target tumour hypoxia. SN29428 is metabolised to a DNA minor groove alkylator via oxygen-sensitive reductive activation initiated by unknown one-electron reductases. The present study sought to identify reductases capable of activating

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service