Skip to Content
Merck
All Photos(1)

Documents

C7522

Sigma-Aldrich

Calcium Ionophore A23187

≥98% (TLC), powder

Synonym(s):

Antibiotic A 23187, Calimycin

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C29H37N3O6
CAS Number:
52665-69-7
Molecular Weight:
523.62
Beilstein:
1096801
EC Number:
258-084-1
MDL number:
MFCD00151202
UNSPSC Code:
12352200
PubChem Substance ID:
24277964
NACRES:
NA.32

sterility

non-sterile

Quality Level

300

Assay

≥98% (TLC)

form

powder

color

white to light yellow

solubility

ethanol: 5 mg/mL (with heating. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)
DMSO: 50 mg/mL (with heating or sonication. Solutions are stable for at least 3 months at -20 °C when protected from light and water contamination.)

antibiotic activity spectrum

Gram-positive bacteria
fungi

Mode of action

cell membrane | interferes

storage temp.

2-8°C

SMILES string

[H][C@@]1(O[C@@]2(CC[C@@H](C)[C@@H](Cc3nc4c(C(O)=O)c(NC)ccc4o3)O2)[C@H](C)C[C@H]1C)[C@H](C)C(=O)c5ccc[nH]5

InChI

1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16-,17-,18-,22-,27+,29+/m1/s1

InChI key

HIYAVKIYRIFSCZ-CYEMHPAKSA-N

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Calcium ionophore A23187 has been used:
  • as an endoplasmic reticulum (ER) stress inducer to study its effect on the expression of the toxoplasma unfolded protein response (UPR) genes
  • for the induction of the acrosome reaction
  • in skeletal muscle sarcoplasmic reticulum Ca2+ ATPase (SERCA) activity assay

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Franz S Gruber et al.
eLife, 9 (2020-01-29)
There is an urgent need to develop new methods for male contraception, however a major barrier to drug discovery has been the lack of validated targets and the absence of an effective high-throughput phenotypic screening system. To address this deficit
Hans Wohlmuth et al.
Journal of natural products, 73(4), 743-746 (2010-03-20)
Bioactivity-guided fractionation of an ethanolic extract of the rhizome of Pleuranthodium racemigerum, a tropical Zingiberaceae species from Northeastern Australia, resulted in the isolation and structural elucidation of 1-(4''-methoxyphenyl)-7-(4'-hydroxyphenyl)-(E)-hept-2-ene (1), a new diarylheptanoid related to curcumin. Compound 1 was a fairly
Gianni Francesco Guidetti et al.
The Biochemical journal, 453(1), 115-123 (2013-04-23)
In blood platelets the small GTPase Rap1b is activated by cytosolic Ca2+ and promotes integrin αIIbβ3 inside-out activation and platelet aggregation. cAMP is the major inhibitor of platelet function and antagonizes Rap1b stimulation through a mechanism that remains unclear. In
Sharissa L Latham et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(2), 672-683 (2012-11-20)
Elevated endothelial microparticle (MP) levels are observed in numerous diseases, increasingly supporting roles as effectors and valuable markers of vascular dysfunction. While a contractile role for the actin cytoskeleton has been implicated in vesiculation, i.e., MP production, the precise interactions
Asuman Mutlu et al.
British journal of haematology, 163(3), 377-384 (2013-09-17)
The cell plasma membrane is tightly coupled with the vital processes of apoptosis and activation. In the current study, we investigated exposure of the apoptosis marker phosphatidylserine (PS) and activation marker P-selectin (CD62) on the plasma membrane of anucleate platelets.
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service