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92732

Supelco

Trimethylsulfonium hydroxide solution

~0.25 M in methanol, for GC derivatization, LiChropur™

Synonym(s):

TMSH

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About This Item

Linear Formula:
(CH3)3S(OH)
CAS Number:
17287-03-5
Molecular Weight:
94.18
Beilstein:
3910286
MDL number:
MFCD00216756
UNSPSC Code:
12000000
PubChem Substance ID:
329770161
NACRES:
NA.22

grade

for GC derivatization

Quality Level

100

form

liquid

quality

LiChropur™

reaction suitability

reagent type: derivatization reagent
reaction type: Alkylations

packaging

pkg of 10 × 1 mL

concentration

~0.25 M in methanol

technique(s)

gas chromatography (GC): suitable

storage temp.

2-8°C

SMILES string

[OH-].C[S+](C)C

InChI

1S/C3H9S.H2O/c1-4(2)3;/h1-3H3;1H2/q+1;/p-1

InChI key

MDTPTXSNPBAUHX-UHFFFAOYSA-M

Related Categories

General description

Trimethylsulfonium hydroxide (TMSH) is a methylating reagent. It can be prepared by dissolving trimethylsulfonium iodide in methanol and water solvent further treating with silver oxide.

Application

TMSH solution has been used as a derivatizing agent in a study to determine the fatty acids in milk samples using thermochemolysis-gas chromatography-mass spectrometry.

Other Notes

Reagent for the methylation of nucleophiles, e.g. carboxylic acids, alcohols, thiols, N-heterocycles; Rapid derivatization of acids for GC by pre-column transesterification of glycerides

Legal Information

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

51.8 °F - closed cup

Flash Point(C)

11 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

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Certificates of Analysis (COA)

Lot/Batch Number
BCCG6745
BCCD6022
BCCB9475
BCBZ5264
BCBV5028

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Direct analysis of fatty acid profile from milk by thermochemolysis?gas chromatography?mass spectrometry.
Reis, Mariza Gomes, et al.
Journal of Chromatography A, 1218.2, 316-323 (2011)
K. Yamauchi et al.
Bulletin of the Chemical Society of Japan, 59, 2947-2947 (1986)
Trimethylsulfonium hydroxide: a new methylating agent.
Yamauchi, Kiyoshi, Toshizumi Tanabe, and Masayoshi Kinoshita.
The Journal of Organic Chemistry, 44.4, 638-639 (1979)
Marco Beccaria et al.
Analytical and bioanalytical chemistry, 410(30), 7987-7996 (2018-10-30)
Gas chromatography (GC) coupled with electron ionization (EI) mass spectrometry (MS) is a well-established technique for the analysis of volatile and semi-volatile compounds. The main advantage is the highly repeatable fragmentation of the compounds into the ion source, generating intense
W. Butte
Journal of Chromatography A, 261, 142-142 (1983)
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