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Iohexol

analytical standard

Synonym(s):

5-[N-(2,3-Dihydroxypropyl)acetamido]-2,4,6-triiodo-N,N′-bis(2,3-dihydroxypropyl)isophthalamide

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About This Item

Empirical Formula (Hill Notation):
C19H26I3N3O9
CAS Number:
Molecular Weight:
821.14
Beilstein:
2406632
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24

grade

analytical standard

Quality Level

Assay

≥95.0% (HPLC)

shelf life

limited shelf life, expiry date on the label

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

impurities

≤6.0% water

application(s)

clinical testing

format

neat

SMILES string

IC1=C(C(NCC(O)CO)=O)C(I)=C(C(NCC(CO)O)=O)C(I)=C1N(CC(CO)O)C(C)=O

InChI

1S/C19H26I3N3O9/c1-8(29)25(4-11(32)7-28)17-15(21)12(18(33)23-2-9(30)5-26)14(20)13(16(17)22)19(34)24-3-10(31)6-27/h9-11,26-28,30-32H,2-7H2,1H3,(H,23,33)(H,24,34)

InChI key

NTHXOOBQLCIOLC-UHFFFAOYSA-N

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General description

Iohexol is a non-ionic, water-soluble contrast agent used as a reference marker to determine the glomerular filtration rate (GFR) which measures the level of kidney function. It finds applications in angiographic and urography procedures.

Application

Iohexol may be used as an internal standard for the determination of iohexol in human plasma, serum and urine samples by HPLC-UV method. It may also be used as a model compound to analyze the applicability of iohexol for glomerular filtration rate (GFR) measurement by the plasma clearance of iohexol in investigating renal failure.
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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Development and validation of an HPLC-UV method for determination of iohexol in human plasma.
Soman R S, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 816(1-2), 339-343 (2005)
Human pharmacokinetics of iohexol. A new nonionic contrast medium.
BO, et al.
Investigative Radiology, 18(2), 177-182 (1983)
Iohexol clearance for GFR-determination in renal failure?single or multiple plasma sampling?.
Sterner G, et al.
Nephrology, Dialysis, and Transplantation, 11(3), 521-525 (1996)
Performance of iohexol determination in serum and urine by HPLC: validation, risk and uncertainty assessment.
Cavalier E, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 396(1-2), 80-85 (2008)
N J Bureau et al.
AJNR. American journal of neuroradiology, 35(8), 1467-1474 (2014-05-31)
Transforaminal corticosteroid injections can be performed in the management of cervical radiculopathy but carry the risk of catastrophic complications. This study compares the efficacy of transforaminal and facet corticosteroid injections at 4 weeks' follow-up. We randomly assigned 56 subjects to

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