MAB16983
Anti-Integrin α4 Antibody, clone P1H4
clone P1H4, Chemicon®, from mouse
Synonym(s):
CD49d
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
P1H4, monoclonal
species reactivity
human, primate
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... ITGA4(3676)
Specificity
The involvement of integrins in vascular proliferation, adhesion, and wound repair and have been well-documented. The integrin family of cell adhesion receptors consists of at least 16 membrane-associated heterodimers, composed of an alpha and beta subunit that associate in a non-covalent manner. The structure and functional diversity of the integrin family are based upon the pairing abilities of the individual alpha and beta subunits. Monoclonal antibody MAB16983 was produced by immunization with human T lymphocytes. The antibody is reactive with integrin a4 from primate and human species.
Application
Anti-Integrin α4 Antibody, clone P1H4 detects level of Integrin α4 & has been published & validated for use in ELISA, FC, IP, IC, IH.
Immunohistochemistry (preferred fixatives are acetone and alcohols)
Immunocytochemistry
Immunoprecipitation
FACS Analysis
ELISA
Radioimmunoassay
Biological Activity: MAB16983 inhibits CS-1 and VCAM binding.
Optimal working dilutions must be determined by end user.
Immunocytochemistry
Immunoprecipitation
FACS Analysis
ELISA
Radioimmunoassay
Biological Activity: MAB16983 inhibits CS-1 and VCAM binding.
Optimal working dilutions must be determined by end user.
Linkage
Replaces: 04-1131
Physical form
Format: Purified
Purified immunoglobulin from Protein A Sepharose™ chromatography. Liquid in 0.02M PB, pH 7.6, 0.25M NaCl containing 0.01% sodium azide.
Storage and Stability
Maintain at +2-8C.
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Sepharose is a trademark of Cytiva
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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A novel RGD-independent fibronectin assembly pathway initiated by alpha4beta1 integrin binding to the alternatively spliced V region.
J L Sechler, A M Cumiskey, D M Gazzola, J E Schwarzbauer
Journal of Cell Science null
Benjamin Hibbert et al.
Cardiovascular research, 83(1), 16-23 (2009-05-21)
Endothelial progenitor cells (EPCs) are circulating pluripotent vascular cells capable of enhancing re-endothelialization and diminishing neointima formation following arterial injury. Glycogen synthase kinase (GSK)-3beta is a protein kinase that has been implicated in the regulation of progenitor cell biology. We
Integrin alpha9beta1 mediates enhanced cell migration through nitric oxide synthase activity regulated by Src tyrosine kinase.
Gupta, SK; Vlahakis, NE
Journal of Cell Science null
PKCepsilon regulation of an alpha5 integrin-ZO-1 complex controls lamellae formation in migrating cancer cells.
Tuomi S, Mai A, Nevo J, Laine JO, Vilkki V, Ohman TJ, Gahmberg CG, Parker PJ, Ivaska J
Science Signaling null
Rika Tanaka et al.
The Journal of biological chemistry, 284(30), 19817-19825 (2009-05-23)
Fibronectin plays important roles in erythropoiesis through the fibronectin receptors VLA-4 and VLA-5. However, the substantial role of these fibronectin receptors and their functional assignment in erythroid differentiation are not yet fully understood. Here, we investigated the effects of cell
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