8.52080

Fmoc-Tyr(2-ClTrt)-OH

Novabiochem^®

• Synonym(s): Fmoc-Tyr(2-ClTrt)-OH, N-α-Fmoc-O-2-chlorotrityl-L-tyrosine
• Empirical Formula (Hill Notation): C₄₃H₃₄ClNO₅
• CAS Number: 350241-80-4
• Molecular Weight: 680.19
• MDL number: MFCD01073759
• UNSPSC Code: 12352209
• NACRES: NA.22

Properties

• Quality Level: 200
• product line: Novabiochem^®
• Assay: ≥98% (TLC); ≥99.0% (HPLC)
• form: powder
• reaction suitability: reaction type: Fmoc solid-phase peptide synthesis
• manufacturer/tradename: Novabiochem^®
• application(s): peptide synthesis
• functional group: hydroxyl
• storage temp.: 2-8°C
• SMILES string: Clc1c(cccc1)C(Oc4ccc(cc4)C[C@H](NC(=O)OCC5c6c(cccc6)c7c5cccc7)C(=O)O)(c3ccccc3)c2ccccc2
• InChI: 1S/C43H34ClNO5/c44-39-22-12-11-21-38(39)43(30-13-3-1-4-14-30,31-15-5-2-6-16-31)50-32-25-23-29(24-26-32)27-40(41(46)47)45-42(48)49-28-37-35-19-9-7-17-33(35)34-18-8-10-20-36(34)37/h1-26,37,40H,27-28H2,(H,45,48)(H,46,47)/t40-/m0/s1

Description

General description

The side-chain ClTrt group can be removed with 1% TFA/ 5% TIS in DCM, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support during Fmoc SPPS.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS


Literature references

^[1] K. Barlos, et al. (1998) J. Peptide Res., 51, 194.

Linkage

Replaces: 04-12-1184

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Water (K. F.): ≤ 4.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable