1.51451
Chromolith® RP-18 endcapped (monolithic) HPLC Columns
L × I.D. 5 mm x 4.6 mm Guard Cartridges (3 pieces)
Synonym(s):
Chromolith® RP-18 endcapped 5-4.6 guard cartridges (3 pieces)
About This Item
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product name
Chromolith® RP-18 endcapped, L × I.D. 5 mm x 4.6 mm guard cartridges (3 pieces)
material
PEEK column
Quality Level
Agency
suitable for USP L1
product line
Chromolith®
feature
endcapped
packaging
pkg of 3 ea
extent of labeling
18% Carbon loading
parameter
400 bar pressure
45 °C max. temp.
technique(s)
HPLC: suitable
LC/MS: suitable
mass spectrometry (MS): suitable (High)
column L × I.D.
0.5 cm × 4.6 mm
matrix
monolithic silica
matrix active group
C18 bonding phase
pore size
13 nm mesoporosity
2 μm macroporosity
operating pH range
2-7.5
separation technique
reversed phase
storage temp.
no temp limit
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General description
Chromolith® RP-18 endcapped 5-4.6 guard cartridges are extremely easy to use. The guard cartridges are simply added directly in front of the main column to protect it from chemical or mechanical contamination. Due to the benefits of monolithic technology, and the convenience of Chromolith® guard columns, they are also popular for use with classical particulate columns. Moreover, guard columns can be used as trap columns when large sample volumes are to be injected. Guard columns should be changed frequently in order to avoid excessive accumulation of impurities.
Chromolith® columns are made of monolithic silica with a characteristic bimodal pore structure.
Chromolith® RP-18 endcapped 5-4.6 guard cartridges are used with the Chromolith® Guard Cartridge Holder 5 mm x 4.6 mm [1.52032]
Learn more:
Brochure: Race through your Separations on Any System. Chromolith® Monolithic Silica HPLC Columns
All Supelco HPLC Columns, including monolithic Chromolith® columns, are fully compatible to all HPLC and UHPLC Instruments.
Supelco HPLC Products: The Best Choice for Any LC Instrument
Application
- Rapid Determination of 30 Polyphenols in Tongmai Formula: This study utilized the Chromolith® RP-18 endcapped column in a liquid chromatography-tandem mass spectrometry setup to analyze 30 polyphenolic compounds in a traditional Chinese medicine formula, demonstrating its application in pharmaceutical analysis and quality control of complex herbal formulations (Wang et al., 2017).
- Ultra-fast gradient LC method for omeprazole analysis using a monolithic column: The Chromolith® RP-18 endcapped column was employed in an ultra-fast gradient liquid chromatography method for the analysis of omeprazole in enteric-coated pellets, highlighting its efficiency in pharmaceutical quality control and rapid method development (Borges et al., 2010).
Analysis Note
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Articles
Monolithic silica HPLC columns enable high-throughput analysis at low back pressure without loss of separation efficiency or peak capacity.
Chromolith® HPLC and UHPLC columns are made from monolithic silica with a bimodal pore structure using sol-gel technology.
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
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