V-032

Voriconazole solution

2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₁₆H₁₄F₃N₅O
• CAS Number: 137234-62-9
• Molecular Weight: 349.31
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: (Snap-N-Spike^®)
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 2.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
• InChI key: BCEHBSKCWLPMDN-MGPLVRAMSA-N

Description

General description

Voriconazole, sold under the trade name Vfend^®, is a triazole antifungal drug prescribed for treatment of serious, invasive fungal infections. This certified Snap-N-Spike^® Solution is suitable as starting material for linearity standards, calibrators, or controls for therapeutic drug monitoring or clinical and diagnostic testing of voriconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

Application

• Solubilization and antifungal activity enhancement: Research highlighted a synthetic citric crosslinked beta-cyclodextrin derivative designed to improve the solubilization and antifungal effectiveness of voriconazole. The study demonstrated enhanced solubility and reduced cytotoxicity, broadening its potential applications in antifungal drug formulation (Soe et al., 2023).


• Rapid quantitative plasma detection: A study developed a method using surface-enhanced Raman scattering to rapidly and quantitatively detect voriconazole in human plasma. This technique supports its use in pharmacokinetic and metabolism research, providing a rapid assessment tool for therapeutic monitoring (Liu et al

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Vfend is a registered trademark of Pfizer, Inc.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup