E-016

Ethyl-β-D-glucuronide

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Empirical Formula (Hill Notation): C₈H₁₄O₇
• CAS Number: 17685-04-0
• Molecular Weight: 222.19
• EC Number: 200-659-6
• MDL number: MFCD09037574
• UNSPSC Code: 41116107
• PubChem Substance ID: 329798946
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): forensics and toxicology
• format: single component solution
• storage temp.: −20°C
• SMILES string: O[C@H]1[C@H](O)[C@@H](C(O)=O)O[C@@H](OCC)[C@@H]1O
• InChI: 1S/C8H14O7/c1-2-14-8-5(11)3(9)4(10)6(15-8)7(12)13/h3-6,8-11H,2H2,1H3,(H,12,13)/t3-,4-,5+,6-,8+/m0/s1
• InChI key: IWJBVMJWSPZNJH-UQGZVRACSA-N

Description

General description

This Certified Reference Material is widely used in forensic analysis and clinical toxicology applications to determine blood alcohol content.

Ethyl-β-D-glucuronide (EtG) is a water-soluble and stable metabolite of ethanol, used as a routine biomarker in alcohol abuse monitoring. A very small fraction of ethanol undergoes degradation to EtG, and it can be detected in body fluids as well as hair.

Application

The certified reference solution (CRM) in solution can also be used as follows:

• Multi-residue analysis of different alcohol metabolites in human blood plasma and urine samples by ultra-high performance liquid chromatography (UHPLC) combined with tandem mass spectrometry (MS/MS)
• Optimization of a supercritical fluid chromatography-tandem mass spectrometric (SFC-MS/MS) method for the separation and quantification of highly polar drugs and their metabolites using an ion-exchange stationary phase from human urine samples
• Evaluation of a paired ion electrospray ionization mass spectrometric (PIESI-MS) approach coupled with high performance liquid chromatographic (HPLC) procedure for the detection and measurement of drug metabolites in urine samples
• Assess the impact of sample preparation of hair samples on the quantitative analysis of ethyl-β-D-glucuronide by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry
• Analysis of ethyl-β-D-glucuronide as a urinary biomarker in human urine samples by a benchtop gas chromatograph coupled with a mass spectrometer (GC-MS)

Features and Benefits

• Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
• Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
• Rigorously tested through real-time stability studies to ensure accuracy and shelf life
• Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
• Flame sealed under argon into ampoules for long-term shelf life
• Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 1
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup