890704C

18:1 EPC (Cl Salt)

Avanti Research^™ - A Croda Brand 890704C

• Synonym(s): 1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt)
• Empirical Formula (Hill Notation): C₄₆H₈₉NO₈PCl
• CAS Number: 474945-24-9
• Molecular Weight: 850.63
• UNSPSC Code: 12352211
• NACRES: NA.25

Properties

• form: liquid
• packaging: pkg of 1 × 2.5 mL (890704C-25mg); pkg of 1 × 4 mL (890704C-100mg); pkg of 2 × 4 mL (890704C-200mg)
• manufacturer/tradename: Avanti Research^™ - A Croda Brand 890704C
• concentration: 10 mg/mL (890704C-25mg); 25 mg/mL (890704C-100mg); 25 mg/mL (890704C-200mg)
• lipid type: transfection; cationic lipids
• shipped in: dry ice
• storage temp.: −20°C
• SMILES string: O=P(OCC[N+](C)(C)C)(OC[C@]([H])(OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)OCC.[Cl-]

Description

General description

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) is a cationic alkylated phospholipid.

Application

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (chloride salt) (18:1 EPC (Cl Salt)) is suitable:

• for composing lipid shell to prepare lipopolyplex/mRNA vaccine
• in solvent-assisted preparation of supported lipid bilayers
• along with 1,2-dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) in mixed liposomes as colloidal vectors for physicochemical study of the DNA compaction
• to formulate the lipid nanoparticle (LNP1) to enhance intracellular delivery mediated by shock waves

Biochem/physiol Actions

1,2-dioleoyl-sn-glycero-3-ethylphosphocholine (18:1 EPC) serves as a transfection reagent. 18:1 EPC is applicable in liposomes and lipoplexes. It is a potential vector in gene therapy.

Packaging

5 mL Clear Glass Sealed Ampule (890704C-100mg)

5 mL Clear Glass Sealed Ampule (890704C-200mg)

5 mL Clear Glass Sealed Ampule (890704C-25mg)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Safety Information

• Pictograms: GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H302,H315,H319,H331,H336,H351,H361d,H372
• Precautionary Statements: P202 - P301 + P312 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
• Target Organs: Liver,Kidney, Respiratory system
• Storage Class Code: 6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
• WGK: WGK 3
• Flash Point(F): does not flash
• Flash Point(C): does not flash