909858
Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide)
PEG average Mn 5,000, PLGA average Mn 20,000, lactide:glycolide 50:50
Synonym(s):
COOH-PEG-PLGA, Carboxylic acid PEG-PLGA
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About This Item
Linear Formula:
H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nC2H3O2
UNSPSC Code:
12352106
NACRES:
NA.23
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form
powder or chunks
feed ratio
lactide:glycolide 50:50
mol wt
PEG average Mn 5,000 (by NMR)
PLGA average Mn 20,000 (by NMR)
color
white to tan
storage temp.
−20°C
Application
Carboxylic acid-poly(ethylene glycol)-b-poly(lactide-co-glycolide) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PLGA block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). The carboxylic acid functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
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