907286

H-L-Photo-Proline hydrochloride

≥95%, for peptide synthesis

• Synonym(s): (S)-1,2,5-Triazaspiro[2.4]hept-1-ene-6-carboxylic acid, Diazirine amino acid, Photo-Pro, Photo-crosslinking amino acid, Photoprobe building block
• Empirical Formula (Hill Notation): C₅H₈ClN₃O₂
• Molecular Weight: 177.59
• UNSPSC Code: 12352101
• NACRES: NA.22

Properties

• product name: H-L-Photo-Proline hydrochloride, ≥95%
• Assay: ≥95%
• form: powder
• reaction suitability: reaction type: solution phase peptide synthesis
• application(s): peptide synthesis
• storage temp.: −20°C

Description

Application

H-L-Photo-Proline HCl is a diazirine-containing proline amino acid and multifunctional probe building blocks. Its incorporation into peptides or small-molecule probes and tools allows for photoaffinity labeling of cellular targets and protein-protein interactions upon UV light (∼360 nm) irradiation to form a covalent bond. This and other multifunctional probe building blocks will continue to accelerate drug discovery research for probing cellular mechanisms, target ID/validation, and understanding traditionally undruggable targets. An Fmoc-protected version is also available as 907324.

Product can be used with our line of photoreactors: Including Penn PhD (Z744035) & SynLED 2.0 (Z744080)

Other Notes

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable