902535

Amino-PEG4-t-butyl ester

• Synonym(s): tert-Butyl 1-amino-3,6,9,12-tetraoxapentadecan-15-oate, H₂N-PEG₄-CH₂CH₂COOtBu, H₂N-dPEG(4)-CO-OtBu
• Empirical Formula (Hill Notation): C₁₅H₃₁NO₆
• CAS Number: 581065-95-4
• Molecular Weight: 321.41
• MDL number: MFCD11041116
• UNSPSC Code: 51171641
• NACRES: NA.22

Properties

• form: liquid
• reaction suitability: reagent type: cross-linking reagent
• refractive index: n/D 1.4508
• density: 1.04479 g/mL
• functional group: amine; ester
• storage temp.: −20°C
• SMILES string: NCCOCCOCCOCCOCCC(OC(C)(C)C)=O
• InChI: 1S/C15H31NO6/c1-15(2,3)22-14(17)4-6-18-8-10-20-12-13-21-11-9-19-7-5-16/h4-13,16H2,1-3H3
• InChI key: PKESARRNSGIDRD-UHFFFAOYSA-N

Description

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophilic PEG linker facilitates solubility in biological applications. Amino-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Legal Information

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable