699918

(R)-N-[(1R,2R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)ureido)cyclohexyl]-tert-butyl-sulfinamide

96%

• Synonym(s): [S(R)]-N-[(1R,2R)-2-[[[[3,5-Bis(trifluoromethyl)phenyl]amino]carbonyl]amino]cyclohexyl]-2-methyl-2-propanesulfinamide
• Empirical Formula (Hill Notation): C₁₉H₂₅F₆N₃O₂S
• CAS Number: 934762-68-2
• Molecular Weight: 473.48
• MDL number: MFCD11656068
• UNSPSC Code: 12352002
• PubChem Substance ID: 329762164
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 96%
• form: solid
• mp: 173-181 °C
• functional group: amine; fluoro
• SMILES string: CC(C)(C)S(=O)N[C@@H]1CCCC[C@H]1NC(=O)Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F
• InChI: 1S/C19H25F6N3O2S/c1-17(2,3)31(30)28-15-7-5-4-6-14(15)27-16(29)26-13-9-11(18(20,21)22)8-12(10-13)19(23,24)25/h8-10,14-15,28H,4-7H2,1-3H3,(H2,26,27,29)/t14-,15-,31-/m1/s1
• InChI key: WMIJNZVQFOPOBW-ZHANGXNJSA-N

Description

Application

(R)-N-[(1R,2R)-2-(3-(3,5-Bis(trifluoromethyl)phenyl)ureido)cyclohexyl]-tert-butyl-sulfinamide is a sulfinamide-urea based chiral catalyst that can be used to synthesize:

• Enantioselective homoallylic amines by asymmetric allylation of acylhydrazones with allylindium reagents.
• Tetrahydroquinolines via an asymmetric Povarov reaction.
• 2-aryl-substituted cycloalkanones by enantioselective protonation of corresponding trimethylsilyl enol ethers.

Safety Information

• Hazard Statements: H413
• Hazard Classifications: Aquatic Chronic 4
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves