Rovis Triazolium Catalyst

Rovis has demonstrated that triazolium salt (667080) in the presence of a base can act as an N-heterocyclic carbene organocatalyst in highly enantioselective intramolecular Stetter reactions. The Stetter reaction (a conjugate addition of an aldehyde to an α,β-unsaturated compound) is a superb method for construction of 1,4-dicarbonyl compounds bearing quaternary stereocenters (Scheme 1).¹

Scheme 1. Rovis Triazolium Catalyst

References

1. Kerr MS, Rovis T. 2004. Enantioselective Synthesis of Quaternary Stereocenters via a Catalytic Asymmetric Stetter Reaction. J. Am. Chem. Soc.. 126(29):8876-8877. https://doi.org/10.1021/ja047644h