- Simultaneous Multiple MS Binding Assays Addressing D
Simultaneous Multiple MS Binding Assays Addressing D
ChemMedChem (2017-08-05)
Marion Schuller, Georg Höfner, Klaus T Wanner
PMID28776962
摘要
MS Binding Assays are a label-free alternative to radioligand binding assays. They provide basically the same capabilities as the latter, but use a non-labeled reporter ligand instead of a radioligand. In contrast to radioligand binding assays, MS Binding Assays offer-owing to the selectivity of mass spectrometric detection-the opportunity to monitor the binding of different reporter ligands at different targets simultaneously. The present study shows a proof of concept for this strategy as exemplified for MS Binding Assays selectively addressing D
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