- TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H
TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H
Frontiers in pharmacology (2017-08-12)
Juan Peng, Zhi-Han Tang, Zhong Ren, Bei He, Yun Zeng, Lu-Shan Liu, Zuo Wang, Dang-Heng Wei, Xi-Long Zheng, Zhi-Sheng Jiang
PMID28798687
摘要
Ten-eleven translocation-2 (TET2) protein is a DNA demethylase that regulates gene expression through DNA demethylation and also plays important roles in various diseases including atherosclerosis. Endothelial dysfunction represents an early key event in atherosclerotic disease. The cystathionine-γ-lyase (CSE)/hydrogen sulfide (H
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