- Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.
Free actin impairs macrophage bacterial defenses via scavenger receptor MARCO interaction with reversal by plasma gelsolin.
American journal of physiology. Lung cellular and molecular physiology (2017-04-08)
Christine M Ordija, Terry Ting-Yu Chiou, Zhiping Yang, Glen M Deloid, Melina de Oliveira Valdo, Zhi Wang, Alice Bedugnis, Terry L Noah, Samuel Jones, Henry Koziel, Lester Kobzik
PMID28385809
摘要
Lung injury can release intracellular actin into the alveolar milieu and is also associated with increased susceptibility to secondary infections. We investigated the effect of free (extracellular) actin on lung macrophage host defense functions. Western blot analysis demonstrated free actin release into the lung lavage fluids of mouse models of ozone injury, influenza infection, and secondary pneumococcal pneumonia and in samples from patients following burn and inhalation injury. Using levels comparable with those observed in lung injury, we found that free actin markedly inhibited murine lung macrophage binding and uptake in vitro of
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