- B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects.
B-type natriuretic peptide increases cortisol and catecholamine concentrations in healthy subjects.
Journal of applied physiology (Bethesda, Md. : 1985) (2016-12-23)
Gabriele Grimm, Michael Resl, Birgit B Heinisch, Martin Hülsmann, Anton Luger, Martin Clodi, Greisa Vila
PMID28008098
摘要
B-type natriuretic peptide (BNP) is a hormone released by the heart in response to volume load and exerts natriuretic properties. It is clinically used as a diagnostic and prognostic biomarker and investigated as a pharmacological agent in the therapy of heart failure. Here we investigate the changes in pituitary, adrenal, and thyroid hormones in response to BNP administration in a randomized single-blinded crossover study conducted in ten healthy men aged 21-29 yr. Participants received in two study sessions a continuous intravenous infusion during 4 h (once placebo and once 3 pmol·kg
材料