The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization.

Nature communications (2016-11-25)

Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann

PMID27882935

摘要

Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4

材料

货号

品牌

产品描述

F8630

Sigma-Aldrich

纤维蛋白原来源于牛血浆, Type I-S, 65-85% protein (≥75% of protein is clottable)

H7125

Sigma-Aldrich

组胺, ≥97.0%

H3149

Sigma-Aldrich

肝素钠盐来源于猪肠粘膜, Grade I-A, ≥180 USP units/mg, powder, BioReagent, suitable for cell culture

EHU058661

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO2

EHU076591

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO1

EHU124361

Sigma-Aldrich

MISSION^® esiRNA, targeting human UNC5B

EHU146321

Sigma-Aldrich

MISSION^® esiRNA, targeting human ROBO4