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Merck

The role of epoxyeicosatrienoic acids in the cardiovascular system.

British journal of clinical pharmacology (2015-02-07)
L Yang, K Mäki-Petäjä, J Cheriyan, C McEniery, I B Wilkinson
摘要

There is increasing evidence suggesting that epoxyeicosatrienoic acids (EETs) play an important role in cardioprotective mechanisms. These include regulating vascular tone, modulating inflammatory responses, improving cardiomyocyte function and reducing ischaemic damage, resulting in attenuation of animal models of cardiovascular risk factors. This review discusses the current knowledge on the role of EETs in endothelium-dependent control of vascular tone in the healthy and in subjects with cardiovascular risk factors, and considers the pharmacological potential of targeting this pathway.

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Sigma-Aldrich
11,12-环氧-(5Z,8Z,14Z)-二十碳三烯酸, ~100 μg/mL in ethanol, ≥95%