- A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.
A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2012-10-03)
Michael K Schultz, Dirk Mueller, Richard P Baum, G Leonard Watkins, Wouter A P Breeman
PMID23026223
摘要
A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15 min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40 MBq nmole(-1) [(68)Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.