- Synthesis and reactivity of novel gamma-phosphate modified ATP analogues.
Synthesis and reactivity of novel gamma-phosphate modified ATP analogues.
Bioorganic & medicinal chemistry letters (2009-05-05)
Sarah E Lee, Lucy M Elphick, Alexandra A Anderson, Laurent Bonnac, Emma S Child, David J Mann, Véronique Gouverneur
PMID19410453
摘要
We hereby present a simple yet novel chemical synthesis of a family of gamma-modified ATPs bearing functional groups on the gamma-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staudinger ligations). A preliminary screen of these compounds as phosphate donors with a typical wild type protein kinase (cdk2) and one of its known substrates p27(kip1) is also presented.