- EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy.
EGRF conjugated PEGylated nanographene oxide for targeted chemotherapy and photothermal therapy.
Biomaterials (2013-06-27)
Hung-Wei Yang, Yu-Jen Lu, Kun-Ju Lin, Sheng-Chieh Hsu, Chiung-Yin Huang, Shu-Han She, Hao-Li Liu, Chih-Wen Lin, Min-Cong Xiao, Shiaw-Pyng Wey, Pin-Yuan Chen, Tzu-Chen Yen, Kuo-Chen Wei, Chen-Chi M Ma
PMID23800742
摘要
Low accumulation of chemotherapeutic agent in tumor tissue and multidrug resistance (MDR) present a major obstacle to curing cancer treatment. Therefore, how to combine several therapeutics in one system is a key issue to overcome the problem. Here, we demonstrate epidermal growth factor receptor (EGFR) antibody-conjugated PEGylated nanographene oxide (PEG-NGO) to carry epirubicin (EPI) for tumor targeting and triple-therapeutics (growth signal blocking, chemotherapy, photothermal therapy) in tumor treatment. This synergistic targeted treatment simultaneously enhances the local drug concentration (6.3-fold) and performs the ultra-efficient tumor suppression to significantly prolong the mice survival (over the course of 50 days).