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Merck
  • Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23.

Nature genetics (2002-05-22)
Jing Li, Ying Yang, Yue Peng, Richard J Austin, Winfried G van Eyndhoven, Ken C Q Nguyen, Tim Gabriele, Mila E McCurrach, Jeffrey R Marks, Timothy Hoey, Scott W Lowe, Scott Powers
PMID12021784
摘要

We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenuation of apoptosis induced by serum starvation and transformation of primary cells in cooperation with RAS.