- Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent.
Synthesis of a novel quinoline derivative, 2-(2-methylquinolin-4-ylamino)-N-phenylacetamide--a potential antileishmanial agent.
Bioorganic & medicinal chemistry (2002-04-09)
Niranjan P Sahu, Chiranjib Pal, Nirup B Mandal, Sukdeb Banerjee, Mausumi Raha, Ashis P Kundu, Anirban Basu, Monidipa Ghosh, Keshab Roy, Santu Bandyopadhyay
PMID11937327
摘要
Some novel quinoline derivatives were prepared and tested for antileishmanial activity. 2-(2-Methylquinolin-4-ylamino)-N-phenylacetamide (2) was found to be significantly more active than the standard antileishmanial drug sodium antimony gluconate (SAG) in reducing the parasite load both in the spleen and liver at a much lower concentration in hamster models. The results suggest that the compound could be exploited as an antileishmanial drug.
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