[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

[Methods for the protection against counterfeit medications. Part 2. The assessment of interlot dispersion of the metoprolol succinate tablets fabricated by different manufacturers].

Sudebno-meditsinskaia ekspertiza (2013-01-01)

V A Iakushev, M A Morozova, T E Elizarova, S B Fitilev, T V Pletneva

摘要

This paper reports the results of analysis of the metoprolol succinate tablets fabricated by two different manufacturers, Akrikhin (Russia) and AstraZeneka (Sweden) by near-IR spectroscopy in the combination with the chemometric processing of the data obtained (discriminative analysis). It is concluded that this method is applicable for the assessment of interlot dispersion of the metoprolol succinate tablets.

材料

货号

品牌

产品描述

M5391

Sigma-Aldrich

美托洛尔 (+)-酒石酸盐, ≥98% (titration), powder

M-123

Supelco

美托洛尔酒石酸酯溶液, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant^®

PHR1076

Supelco

美托洛尔 (+)-酒石酸盐, Pharmaceutical Secondary Standard; Certified Reference Material

M1830000

美托洛尔 (+)-酒石酸盐, European Pharmacopoeia (EP) Reference Standard