- Nickel-catalyzed reductive methylation of alkyl halides and acid chlorides with methyl p-tosylate.
Nickel-catalyzed reductive methylation of alkyl halides and acid chlorides with methyl p-tosylate.
Organic letters (2014-10-22)
Zhuye Liang, Weichao Xue, Kunhua Lin, Hegui Gong
PMID25333482
摘要
Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions.
材料