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Merck
  • Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis.

Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis.

Bioorganic & medicinal chemistry letters (2009-04-01)
André Luís Branco de Barros, Valbert Nascimento Cardoso, Luciene das Graças Mota, Elaine Amaral Leite, Mônica Cristina de Oliveira, Ricardo José Alves
摘要

A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, d-glucose-MAG(3) is a potential agent for tumor diagnosis.

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Sigma-Aldrich
1-叠氮-1-脱氧-β-D-吡喃葡萄糖苷