Effect of high level bovine parathyroid extracts on serum PTH, cAMP and urinary cAMP, Na+, and uric acid in stone-forming patients.

Patients with a history of idiopathic calcium oxalate stones, but without current stone formation, show distinctly higher levels of serum cAMP (cyclic adenosine 3',5'-monophosphate) after rapid injection of an extreme concentration of parathyroid extract (PTE). Extreme parathyroid hormone (PTH) levels, as induced by rapid injection of biologically active bovine PTEs, significantly affect the renal generation of cAMP and the elimination of electrolytes in a healthy control group. The stimulated increase of urinary cAMP, sodium, potassium, calcium and phosphate are observed to return to normal levels 120 min after extreme PTE injections for both groups studied.