- Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.
Bioorganic & medicinal chemistry letters (2005-10-12)
Andrew Burchat, David W Borhani, David J Calderwood, Gavin C Hirst, Biqin Li, Robert F Stachlewitz
PMID16216497
摘要
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
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