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Merck
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主要文件

SML2913

Sigma-Aldrich

Dehydroxylcannabidiol

≥98% (HPLC)

别名:

2-[(1R,6R)-3-Methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-5-pentylphenol, DH-CBD

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About This Item

经验公式(希尔记法):
C21H30O
分子量:
298.46
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

oil

光學活性

[α]/D -135 to -120°, c = 0.5 in chloroform-d

顏色

colorless to light brown

儲存溫度

2-8°C

生化/生理作用

Dehydroxylcannabidiol (DH-CBD) is a synthetic nonpsychoactive cannabinoid that alleviate acute pain and chronic inflammatory pain by targeting α3 GlyRs. Dehydroxylcannabidio restores the function of both hyperekplexic mutant GlyRα1 and GABAAR in the presence of GlyRα1R271Q. Apparently dehydroxylcannabidiol interrupts the protein interaction GlyRα1 and GABAAR.

象形圖

Health hazardExclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Repr. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Wei Xiong et al.
The Journal of experimental medicine, 209(6), 1121-1134 (2012-05-16)
Certain types of nonpsychoactive cannabinoids can potentiate glycine receptors (GlyRs), an important target for nociceptive regulation at the spinal level. However, little is known about the potential and mechanism of glycinergic cannabinoids for chronic pain treatment. We report that systemic

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