F2293

Follicle Stimulating Hormone from porcine pituitary

• 别名: FSH, Follitropin, pFSH
• CAS号: 9002-68-0
• MDL號碼: MFCD00131099
• 分類程式碼代碼: 12352209
• eCl@ss: 42020504
• NACRES: NA.32
• 生物源: Porcine
• 形狀: powder

属性

• 生物源: Porcine
• 品質等級: 200
• 形狀: powder
• 包裝: pkg of 50 unit per vial
• 技術: cell culture | mammalian: suitable
• 溶解度: H₂O: soluble 50 mg/mL
• UniProt登錄號: P01228; P23945
• 儲存溫度: 2-8°C
• InChI: 1S/C79H125N19O23S/c1-39(2)34-53(90-67(110)51(27-29-57(102)103)87-66(109)49(20-14-15-31-80)86-70(113)54(35-45-18-12-11-13-19-45)92-76(119)63(43(9)99)96-65(108)48(81)38-122)72(115)93-60(40(3)4)75(118)91-55(36-46-23-25-47(101)26-24-46)71(114)88-52(28-30-58(104)105)69(112)97-64(44(10)100)77(120)94-61(41(5)6)74(117)89-50(21-16-32-84-79(82)83)68(111)95-62(42(7)8)78(121)98-33-17-22-56(98)73(116)85-37-59(106)107/h11-13,18-19,23-26,39-44,48-56,60-64,99-101,122H,14-17,20-22,27-38,80-81H2,1-10H3,(H,85,116)(H,86,113)(H,87,109)(H,88,114)(H,89,117)(H,90,110)(H,91,118)(H,92,119)(H,93,115)(H,94,120)(H,95,111)(H,96,108)(H,97,112)(H,102,103)(H,104,105)(H,106,107)(H4,82,83,84)/t43-,44-,48+,49+,50+,51+,52+,53+,54+,55+,56+,60+,61+,62+,63+,64+/m1/s1
• InChI 密鑰: RPJRYFRWJUYJGY-AYWRSWFDSA-N
• 基因資訊: human ... FSHR(2492) ; pig ... FSHB(396895)

说明

一般說明

FSH (follicle stimulating hormone) protein is composed of two subunits- α and β, where α subunit has resemblance to LH, hCG and TSH, which are glycoprotein hormones. α subunit has one glycosylation site and β subunit has two.

應用

Follicle stimulating hormone from porcine pituitary has been used for the in vitro maturation, fertilization and co-culture of cumulus oocyte complex and the co-culture of primary germ and Sertoli cells obtained from adult rat testes.

生化／生理作用

FSH in involved in the growth of ovarian follicles and steroidogenesis of ovaries. FSHR (follicle stimulating hormone receptor) interacts with FSH in the ovaries, and determines the responsiveness to this hormone. Depressed levels of FSHR result in poor responsiveness and influence folliculogenesis. In Caucasian population, certain polymorphisms in this gene are more commonly found in patients with polycystic ovary syndrome (PCOS).

The α-chain is not active; biological specificity is attributed to the β-chain. Induces maturation of Graafian follicles of the ovary; promotes development of germinal cells in males; activates cytosolic tyrosine kinase.

其他說明

Two-chain glycoprotein hormone

單位定義

One unit is the activity of 1 mg of Armour FSH Standard G-94 by the method of Steelman, S.L., and Pohley, F.M., Endocrinology, 53, 604 (1953).

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable