D1694
Anti-DYRK1A (N-terminal) antibody produced in rabbit
~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Dual-specificity tyrosine-phosphorylation-regulated kinase 1A, Anti-MBN/MNBH, Anti-MNB protein kinase, Anti-Minibrain Drosophila homolog
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
NACRES:
NA.41
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen ~86 kDa
物種活性
rat, mouse, human
濃度
~1.5 mg/mL
技術
western blot: 1.5-3 μg/mL using rat brain embryonic extract (S1 fraction)
western blot: 3-5 μg/mL using PC12 cell lyste
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... DYRK1A(1859)
mouse ... Dyrk1a(13548)
rat ... Dyrk1a(25255)
一般說明
DYRK1A (dual-specificity tyrosine-phosphorylated regulated kinase 1A) is a member of a growing family of Ser/Thr protein kinases termed DYRKs.
The human and rodent DYRK1A are ubiquitously expressed in adult and fetal tissue with high expression in the brain and heart during development.
應用
Anti-DYRK1A (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunohistochemistry.
生化／生理作用
DYRK1A is encoded by a gene located within the Down syndrome (DS) critical region on human chromosome 21 and its expression is found to be elevated in individuals with DS. It might be one of the genes involved in some of the neurological abnormalities observed in DS. It phosphorylates several substrates including transcription factor FKHR, NFAT, STAT3, microtubule-associated protein Tau, glycogen synthase and c-AMP-response element-binding protein.
標靶描述
DYRK1A (N-terminal) encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-c
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves
Mark Meyers et al.
The Journal of biological chemistry, 280(7), 5516-5526 (2004-12-22)
Previous studies from our laboratory indicated that expression of the MLH1 DNA mismatch repair (MMR) gene was necessary to restore cytotoxicity and an efficient G(2) arrest in HCT116 human colon cancer cells, as well as Mlh1(-/-) murine embryonic fibroblasts, after
Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in mice
Fotaki V, et al.
Molecular and cellular biology, 22(18), 6636-6647 (2002)
Manon Moreau et al.
Biomedicines, 10(6) (2022-06-25)
Down syndrome (DS) is a complex genetic condition due to an additional copy of human chromosome 21, which results in the deregulation of many genes. In addition to the intellectual disability associated with DS, adults with DS also have an
Protein profile and morphological alterations in penumbra after focal photothrombotic infarction in the rat cerebral cortex
Uzdensky A, et al.
Molecular Neurobiology, 54(6), 4172-4188 (2017)
Benoît Souchet et al.
Acta neuropathologica communications, 7(1), 46-46 (2019-03-20)
Recent evidences suggest the involvement of DYRK1A (dual specificity tyrosine phosphorylation-regulated kinase 1 A) in Alzheimer's disease (AD). Here we showed that DYRK1A undergoes a proteolytic processing in AD patients hippocampus without consequences on its kinase activity. Resulting truncated forms
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