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Merck

Y0000803

乙胺丁醇

European Pharmacopoeia (EP) Reference Standard

别名:

乙胺丁醇 二盐酸盐, 2,2#8242;-(1,2- Ethanediyldiimino)-1-丁醇 二盐酸盐, Emb

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About This Item

经验公式(希尔记法):
C10H24N2O2 · 2HCl
CAS号:
分子量:
277.23
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

ethambutol

製造商/商標名

EDQM

應用

pharmaceutical (small molecule)

格式

neat

儲存溫度

2-8°C

SMILES 字串

CC[C@@H](CO)NCCN[C@H](CO)CC.Cl.Cl

InChI

1S/C10H24N2O2.2ClH/c1-3-9(7-13)11-5-6-12-10(4-2)8-14;;/h9-14H,3-8H2,1-2H3;2*1H/t9-,10-;;/m0../s1

InChI 密鑰

AUAHHJJRFHRVPV-BZDVOYDHSA-N

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

乙胺丁醇是一种分枝杆菌抗菌剂,与其他抗生素联合使用可治疗结核病,减缓耐药性的发展进程。在中国结核病发病率最高的地区,长期用于研究耐多药结核病(MDR-TB)。

生化/生理作用

乙胺丁醇对活跃生长的结核杆菌具有抗菌作用。分枝菌酸附着在阿拉伯半乳聚糖的 D-阿拉伯糖残基的 5′-羟基上,并在细胞壁中形成分枝酸- 阿拉伯半乳糖-肽聚糖复合层。乙胺丁醇通过抑制阿拉伯糖基转移酶,特别是分枝杆菌中的阿拉伯糖基转移酶,干扰阿拉伯半乳聚糖的合成,通过干扰分枝杆菌细胞壁中的阿拉伯半乳聚糖的生物合成,并导致细胞壁渗透性增加。

包裝

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

其他說明

Sales restrictions may apply.

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Tuberculosis (TB) is a worldwide health concern. In 2011, about 8.7 million new cases developed TB and 1.4 million people died from it. Enhancement of ethambutol hydrochloride activity and safety in treatment of TB through niosomal encapsulation. Niosomes were prepared
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