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Merck

PSEN1

presenilin 1

别名:
AD3, FAD, PS-1, PS1, S182
物种:
UniProtKB ID:
基因ID:
  • Human(5663) Summary: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
  • Mouse(19164) presenilin 1
  • Rat(29192) presenilin 1
  • cow(282705) presenilin 1
  • sheep(101102488) presenilin 1
  • naked mole-rat(101716186) presenilin 1
  • Domestic Rabbit(100008886) presenilin 1
  • domestic guinea pig(100728153) presenilin 1
  • Zebrafish(30221) presenilin 1
  • domestic cat(101087239) presenilin 1
  • dog(403408) presenilin 1
  • chicken(373977) presenilin 1

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ELISA

货号
说明
物种
人早老素1 ELISA, for serum, plasma and cell culture supernatants,
物种
human

Antibodies

货号
说明
物种反应性
应用
抗早老素1抗体(NT,克隆hPS1-NT), culture supernatant, clone hPS1-NT, Chemicon®,
物种反应性
human
应用
ELISA
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Presenilin-1 Antibody, clone PS1-loop ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse
应用
ELISA
affinity binding assay

immunocytochemistry

western blot
Anti-Presenilin1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
物种反应性
human, mouse, rat
应用
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-PSEN1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Anti-Presenilin-1 Antibody, loop, a.a. 275-367, CT, serum, Chemicon®,
物种反应性
hamster, human, monkey, mouse
应用
immunocytochemistry
immunoprecipitation (IP)

western blot

Small Molecule - Inhibitor

货号
说明
物种
Begacestat, ≥98% (HPLC),
物种
human
DAPT, ≥98% (HPLC), solid,
物种
mouse, human, rat
L-685,458, >96% (HPLC), solid,
物种
mouse, human, rat

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Psen1,
物种
mouse
MISSION® esiRNA, targeting human PSEN1,
物种
human