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Merck

CHEK1

checkpoint kinase 1

别名:
CHK1
物种:
Human CHEK1 (1111), Mouse Chek1 (12649), Rat Chek1 (140583), Zebrafish chek1 (393162), domestic cat CHEK1 (101083365), Horse CHEK1 (100064353), cow CHEK1 (513678), dog CHEK1 (609767), sheep CHEK1 (101111403), naked mole-rat Chek1 (101701035)
UniProtKB ID:
O14757, A8K934, B4DDD0, B4DSK3, B5BTY6, F5H7S4, H2BI51
基因ID:
  • Human(1111) Summary: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011]
  • Mouse(12649) checkpoint kinase 1
  • Rat(140583) checkpoint kinase 1
  • Zebrafish(393162) CHK1 checkpoint homolog (S. pombe)
  • domestic cat(101083365) checkpoint kinase 1
  • Horse(100064353) checkpoint kinase 1
  • cow(513678) CHK1 checkpoint homolog (S. pombe)
  • dog(609767) checkpoint kinase 1
  • sheep(101111403) checkpoint kinase 1
  • naked mole-rat(101701035) checkpoint kinase 1
  • domestic guinea pig(100719613) checkpoint kinase 1

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Antibodies

货号
说明
物种反应性
应用
C9358
Anti-Chk1 antibody, Mouse monoclonal, ~2 mg/mL, clone DCS-310, purified from hybridoma cell culture,
物种反应性
human
应用
immunohistochemistry
immunoprecipitation (IP)
microarray
western blot
AV32589
Anti-CHEK1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
dog, horse, human, mouse, rabbit, rat
应用
immunohistochemistry
western blot
SAB4500211
Anti-CHK1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
SAB4504365
Anti-phospho-Chk1 (pSer345) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
ZRB2313
Anti-Chk1 Antibody, clone 2E14 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
canine, feline, human, monkey, mouse, porcine
应用
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

货号
说明
物种
U6508
UCN-01, ≥97% (HPLC), powder,
物种
human

Proteins

货号
说明
物种
SRP5278
CHK1, active, His tagged human, PRECISIO®, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
14-346-M
CHK1 Protein, active, 10 µg, Active, N-terminal GST tagged, human full length CHK1, for use in Kinase Assays.,
物种
human
12-414
CHKtide, biotin conjugate, ,
物种
human
C0870
CHK1, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human

esiRNA

货号
说明
物种
EHU056141
MISSION® esiRNA, targeting human CHEK1,
物种
human

Small Molecule - Substrate

货号
说明
物种
12-373
CHKtide (CHK1/CHK2 substrate peptide), CHKtide (CHK1/CHK2 substrate peptide) primarily used in Kinase Assays.,
物种
human