CDKN1B
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
别名:
CDKN4, KIP1, MEN1B, MEN4, P27KIP1
物种:
Human CDKN1B (1027), Mouse Cdkn1b (12576), Rat Cdkn1b (83571), chicken CDKN1B (374106), dog CDKN1B (403429), cow CDKN1B (512613), domestic cat CDKN1B (493958), chicken CDKN1B (769872), naked mole-rat Cdkn1b (101698721), domestic guinea pig Cdkn1b (100729359) ...展开
UniProtKB ID:
基因ID:
- Human(1027) Summary: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq, Jul 2008]
- Mouse(12576) cyclin-dependent kinase inhibitor 1B
- Rat(83571) cyclin-dependent kinase inhibitor 1B
- chicken(374106) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- dog(403429) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- cow(512613) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- domestic cat(493958) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- chicken(769872) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- naked mole-rat(101698721) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- domestic guinea pig(100729359) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- sheep(100127219) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
- Domestic Rabbit(100009037) cyclin-dependent kinase inhibitor 1B (p27, Kip1)
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Antibodies
货号
说明
物种反应性
应用
Anti-phospho-p27 Kip1 (pThr198) antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
western blot
Monoclonal Anti-CDKN1B antibody produced in mouse, clone 4B4-E6, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
ELISA
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
immunofluorescence
immunohistochemistry
proximity ligation assay
western blot
抗Kip1（p27）抗体, Upstate®, from rabbit,
物种反应性
human, rabbit, rat
应用
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Small Molecule - Inhibitor
Proteins
货号
说明
物种
p27KIP1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
物种
human
p27 Protein complex, activated, 10 µg, Activated complex of three (3) full length, recombinant human proteins: p27, Cyclin E1, & CDK2. Phosphorylated in vitro using CDK2/Cyclin E1. For use in Enzyme Assays. Behaves as a substrate in ubiquitin assays.,
物种
human