BPTF
bromodomain PHD finger transcription factor
别名:
FAC1, FALZ, NURF301
物种:
Human BPTF (2186), Mouse Bptf (207165), Rat Bptf (303617), Zebrafish bptf (324479), chicken BPTF (100858895), dog BPTF (480467), domestic cat BPTF (101085933), cow BPTF (532986), Horse BPTF (100063881), domestic guinea pig Bptf (100735351) ...展开
UniProtKB ID:
基因ID:
- Human(2186) Summary: This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
- Mouse(207165) bromodomain PHD finger transcription factor
- Rat(303617) bromodomain PHD finger transcription factor
- Zebrafish(324479) bromodomain PHD finger transcription factor
- chicken(100858895) bromodomain PHD finger transcription factor
- dog(480467) bromodomain PHD finger transcription factor
- domestic cat(101085933) bromodomain PHD finger transcription factor
- cow(532986) bromodomain PHD finger transcription factor
- Horse(100063881) bromodomain PHD finger transcription factor
- domestic guinea pig(100735351) bromodomain PHD finger transcription factor
- naked mole-rat(101710448) bromodomain PHD finger transcription factor
- sheep(101102998) bromodomain PHD finger transcription factor
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Antibodies
货号
说明
物种反应性
应用
Anti-BPTF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
物种反应性
human
应用
immunofluorescence
Anti-BPTF antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-BPTF Antibody, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse
应用
immunoprecipitation (IP)
western blot
western blot
抗-BPTF（VCU19）, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, rat
应用
ChIP
western blot
western blot
Anti-BPTF Antibody, clone 15B1.1, clone 15B1.1, from mouse,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
western blot