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Merck

ACLY

ATP citrate lyase

别名:
ACL, ATPCL, CLATP
物种:
UniProtKB ID:
基因ID:
  • Human(47) Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(104112) ATP citrate lyase
  • Rat(24159) ATP citrate lyase
  • chicken(395373) ATP citrate lyase
  • Horse(100053195) ATP citrate lyase
  • cow(511135) ATP citrate lyase
  • domestic cat(100422779) ATP citrate lyase
  • dog(607852) ATP citrate lyase
  • naked mole-rat(101700349) ATP citrate lyase
  • domestic guinea pig(100714933) ATP citrate lyase
  • sheep(654404) ATP citrate lyase

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Antibodies

货号
说明
物种反应性
应用
Anti-ACLY, clone 5F8D11 Antibody, clone 5F8D11, from mouse,
物种反应性
human, monkey, mouse
应用
ELISA
flow cytometry

immunofluorescence

immunohistochemistry

western blot
Anti-ACLY antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
物种反应性
human, mouse, rat
应用
immunofluorescence
immunohistochemistry

western blot
Anti-ATP-citrate synthase/ACLY Antibody, from rabbit, purified by affinity chromatography,
物种反应性
bovine, human, mouse, porcine, rat, sheep
应用
immunohistochemistry
western blot
Anti-ACLY Antibody, clone 1B16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-Phospho-ACLY-S455 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
immunoprecipitation (IP)

western blot

Proteins

货号
说明
物种
ATP枸橼酸裂解酶活性 人, recombinant, expressed in baculovirus, ≥90% (SDS-PAGE),
物种
human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting mouse Acly,
物种
mouse
MISSION® esiRNA, targeting human ACLY,
物种
human