Yudin Group – Professor Product Portal
Professor Andrei Yudin
The Yudin Laboratory is known for the development of amphoteric molecules and their application in synthesis. The corresponding reagents possess nucleophilic and electrophilic functional groups that do not prematurely react with each other. Over the years, Yudin and his students have developed a series of processes based on aziridine aldehydes, alpha-boryl aldehydes, and acyl boronates. These molecules have been applied in the synthesis of medicinally relevant heterocycles, macrocycles, and peptidomimetics. The mild reaction conditions, minimal reliance on protecting groups, and possibility to obtain scaffolds that are not accessible by other means are the main differentiating features of this technology.
Recent papers from the Yudin Group
1.
Hili R, Yudin AK. 2006. Readily Available Unprotected Amino Aldehydes. J. Am. Chem. Soc.. 128(46):14772-14773. https://doi.org/10.1021/ja065898s
2.
He Z, Yudin AK. 2011. Amphoteric ?-Boryl Aldehydes. J. Am. Chem. Soc.. 133(35):13770-13773. https://doi.org/10.1021/ja205910d
3.
He Z, Trinchera P, Adachi S, St.?Denis JD, Yudin AK. 2012. Oxidative Geminal Functionalization of Organoboron Compounds. Angew. Chem. Int. Ed.. 51(44):11092-11096. https://doi.org/10.1002/anie.201206501
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DISCIPLINES
- Organic Synthetic Chemistry
- Catalysis
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