SRP0327

PADI-2 human

recombinant, expressed in baculovirus infected Sf9 cells, ≥60% (SDS-PAGE)

• Synonym(s): Peptidyl arginine deiminase, type II
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• biological source: human
• recombinant: expressed in baculovirus infected Sf9 cells
• Assay: ≥60% (SDS-PAGE)
• form: aqueous solution
• mol wt: 77 kDa
• packaging: pkg of 10 μg
• NCBI accession no.: NM_007365
• UniProt accession no.: Q9Y2J8
• shipped in: dry ice
• storage temp.: −70°C
• Gene Information: human ... PADI2(11240)

Description

General description

Human PADI2, also known as Peptidyl arginine deiminase, type II, (GenBank Accession No. NM_007365), amino acids 1-665 (end) with C-terminal FLAG-tag, MW= 77kDa, expressed in a Baculovirus infected Sf9 cell expression system. Peptidyl arginine deiminase, protein-2 (PADI2) is mapped to human chromosome 1p36. It is expressed in Sertoli cells at the time of testicular development.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. PADI-2 human has been used in in vitro binding assays.

Biochem/physiol Actions

Peptidyl arginine deiminase, protein-2 (PADI2) promotes protein citrullination and represses the multiplication of cells. It helps to transform the amino acid arginine in a protein into amino acid citrulline. PADI2 participates in epigenetic mechanisms. It is linked with rheumatoid arthritis.

Physical form

Formulated in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/uL Flag peptide, 3 mMDTT, and 20% Glycerol.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable