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SML2187

Sigma-Aldrich

RL5a

≥98% (HPLC)

Synonym(s):

N2-[2-(2-Furanyl)-4-quinolinyl]-N1,N1-dimethyl-1,2-ethanediamine

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About This Item

Empirical Formula (Hill Notation):
C17H19N3O
CAS Number:
133671-66-6
Molecular Weight:
281.35
MDL number:
MFCD00929354
UNSPSC Code:
12352200
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

white to very dark brown

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

InChI

1S/C17H19N3O/c1-20(2)10-9-18-15-12-16(17-8-5-11-21-17)19-14-7-4-3-6-13(14)15/h3-8,11-12H,9-10H2,1-2H3,(H,18,19)

InChI key

CRGKLHXVNVZAPA-UHFFFAOYSA-N

Biochem/physiol Actions

RL5a is a potent inhibitor of the replication licensing system in human cells. RL5a blocks the binding of the origin recognition complex (ORC) to origin DNA, which is required interaction for licensing. RL5a appears to act as noncompetitive inhibitor of ORC with respect to ATP.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Certificates of Analysis (COA)

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Nicola J Gardner et al.
Cell chemical biology, 24(8), 981-992 (2017-08-07)
In late mitosis and G

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