SML1725

RTC13

≥98% (HPLC)

• Synonym(s): (5Z)-2-Amino-5-[[5-(2-nitrophenyl)-2-furanyl]methylene]-4(5H)-thiazolone, (Z)-2-Amino-5-((5-(2-nitrophenyl)furan-2-yl)methylene)thiazolidin-4-one
• Empirical Formula (Hill Notation): C₁₄H₉N₃O₄S
• CAS Number: 1359825-94-7
• Molecular Weight: 315.30
• MDL number: MFCD00808624
• UNSPSC Code: 12352200
• PubChem Substance ID: 329826040
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: yellow to orange
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: O=C1NC(S/C1=C\C2=CC=C(C3=C([N+]([O-])=O)C=CC=C3)O2)=N
• InChI: 1S/C14H9N3O4S/c15-14-16-13(18)12(22-14)7-8-5-6-11(21-8)9-3-1-2-4-10(9)17(19)20/h1-7H,(H2,15,16,18)/b12-7+
• InChI key: CZZAPCPWFCGOCC-KPKJPENVSA-N

Description

Biochem/physiol Actions

RTC13 is a cell-permeable thiazolidinone derivative that promotes ribosomal read-through activity of premature termination codons (PTCs) and effectively restores full-length protein production from transcripts containing nonsense mutations-generated PTCs, including ataxia-telangiectasia (A-T) mutated in A-T lymphoblastoid cell cultures and dystrophin in mdx Duchenne muscular dystrophy (DMD) mice-derived muscle myotubes.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable