SML0481

Qc1

≥98% (HPLC)

• Synonym(s): 1,2,3,4-Tetrahydro-4-oxo-N-(phenylmethyl)-2-thioxo-3-[3-(trifluoromethyl)phenyl]-7-quinazolinecarboxamide
• Empirical Formula (Hill Notation): C₂₃H₁₆F₃N₃O₂S
• CAS Number: 403718-45-6
• Molecular Weight: 455.45
• MDL number: MFCD02649259
• UNSPSC Code: 12352200
• PubChem Substance ID: 329825432
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL (clear solution, warmed)
• storage temp.: 2-8°C
• SMILES string: FC(F)(F)c1cccc(c1)N2C(=S)Nc3cc(ccc3C2=O)C(=O)NCc4ccccc4
• InChI: 1S/C23H16F3N3O2S/c24-23(25,26)16-7-4-8-17(12-16)29-21(31)18-10-9-15(11-19(18)28-22(29)32)20(30)27-13-14-5-2-1-3-6-14/h1-12H,13H2,(H,27,30)(H,28,32)
• InChI key: IFNVTSPDMUUAFY-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Qc1 is a reversible inhibitor of threonine dehydroxygenase (TDH). The IC₅₀ value for inhibition of TDH by Qc1 is 500 nM, with no detectable inhibition of other dehydroxygenase enzymes at concentrations up to 10 mM. Qc1 induces arrest and autophagy of mouse ES cells with an EC₅₀ of 3 mM.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable