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About This Item
Empirical Formula (Hill Notation):
C22H37N9O10
Molecular Weight:
587.58
UNSPSC Code:
12352209
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥60%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
Gly-Arg-Gly-Asp-Ser-Pro
General description
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is a bioactive molecule/peptide derived from fibronectin.
Application
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) has been used:
- in coating well plate to monitor cell attachment by crystal violet staining
- to treat baby hamster kidney (BHK-21) cells to study the role of Arg-Gly-Asp (RGD) motif in the replication of Japanese encephalitis virus (JEV)
- to block RGD-dependent integrins or integrin signaling in INA-6 cells
- to study the role of the RGD-binding integrins in Gal-3-mediated cell adhesion
Biochem/physiol Actions
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can stimulate endothelialization by modifying the surface of cardiovascular implants. The major cell- binding domain of GRGDSP helps to promote cell adhesion on a wide range of substrates.
Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) is used as a soluble integrin-blocking RGD-based peptide. GRGDSP is used widely together with other RGD peptides in integrin research.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Shyam Patel et al.
Journal of biomedical materials research. Part A, 83(2), 423-433 (2007-04-25)
Vascular endothelium plays an important role in preventing thrombogenesis. Bioactive molecules such as fibronectin-derived peptide Gly-Arg-Gly-Asp-Ser-Pro (GRGDSP) can be used to modify the surface of cardiovascular implants such as vascular grafts to promote endothelialization. Here we conjugated GRGDSP peptide to
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