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PZ0377

Sigma-Aldrich

PF-05236216 hydrochloride

≥98% (HPLC)

Synonym(s):

4-[3-(4-Fluorophenyl)-1-methyl-1H-pyrazol-4-yl]-6,7-dihydro-6-methyl-5H-pyrrolo[3,4-b]pyridin-5-one hydrochloride, PF-5236216 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C18H15FN4O · HCl
CAS Number:
Molecular Weight:
358.80
UNSPSC Code:
51111800
NACRES:
NA.77

Pricing and availability is not currently available.

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN1C=C(C2=CC=NC(CN3C)=C2C3=O)C(C4=CC=C(F)C=C4)=N1.Cl

InChI

1S/C18H15FN4O.ClH/c1-22-10-15-16(18(22)24)13(7-8-20-15)14-9-23(2)21-17(14)11-3-5-12(19)6-4-11;/h3-9H,10H2,1-2H3;1H

InChI key

CLDJMFXSCFWXDI-UHFFFAOYSA-N

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This Item
PZ0328PZ0406PZ0351
form

powder

form

powder

form

powder

form

powder

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

room temp

storage temp.

room temp

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL, clear (warmed)

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

storage condition

desiccated

storage condition

desiccated

storage condition

-

storage condition

desiccated

color

white to beige

color

white to beige

color

white to beige

color

white to brown

Biochem/physiol Actions

PF-05236216 is a brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε) that modulates circadian rhythms in mice.
brain penetrant, potent and selective inhibitor of casein kinase 1 delta/epsilon (CK1δ/ε)

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Scot Mente et al.
Journal of medicinal chemistry, 56(17), 6819-6828 (2013-08-08)
Casein kinase 1δ (CK1δ) and 1ε (CK1ε) are believed to be necessary enzymes for the regulation of circadian rhythms in all mammals. On the basis of our previously published work demonstrating a CK1ε-preferring compound to be an ineffective circadian clock
Travis T Wager et al.
ACS chemical neuroscience, 8(9), 1995-2004 (2017-06-14)
To enable the clinical development of our CNS casein kinase 1 delta/epsilon (CK1δ/ε) inhibitor project, we investigated the possibility of developing a CNS positron emission tomography (PET) radioligand. For this effort, we focused our design and synthesis efforts on the

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