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O7125

Sigma-Aldrich

L-Ornithine L-aspartate salt

≥98% (TLC)

Synonym(s):

(S)-2,5-Diaminopentanoic acid L-aspartate salt

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About This Item

Empirical Formula (Hill Notation):
C9H19N3O6
CAS Number:
3230-94-2
Molecular Weight:
265.26
EC Number:
221-772-7
MDL number:
MFCD00058084
UNSPSC Code:
12352209
PubChem Substance ID:
329818920
NACRES:
NA.26

product name

L-Ornithine L-aspartate salt, powder

Assay

≥98% (TLC)

form

powder

color

white to off-white

storage temp.

2-8°C

SMILES string

NCCC[C@H](N)C(O)=O.N[C@@H](CC(O)=O)C(O)=O

InChI

1S/C5H12N2O2.C4H7NO4/c6-3-1-2-4(7)5(8)9;5-2(4(8)9)1-3(6)7/h4H,1-3,6-7H2,(H,8,9);2H,1,5H2,(H,6,7)(H,8,9)/t4-;2-/m00/s1

InChI key

IXUZXIMQZIMPSQ-ZBRNBAAYSA-N

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Biochem/physiol Actions

L-Ornithine L-aspartate is a metabolite of arginine degradation by arginase. It has been shown to reduce blood ammonia concentrations by increasing ammoniadetoxification in the muscle and reducing the severity of hepatic encephalopathy in cirrhosis.

Other Notes

Product of arginine degradation by arginase

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Babette Linde et al.
Medizinische Klinik (Munich, Germany : 1983), 102(10), 846-851 (2007-10-12)
Fulminate liver insufficiency can have many causes and is a challenge for differential diagnosis. A 39-year-old woman was admitted because of a nonitching macular-papular exanthema on both thighs with spreading to the trunk. In addition, the patient complained of dysphagia
Gavin Wright et al.
Liver international : official journal of the International Association for the Study of the Liver, 31(2), 163-175 (2010-08-03)
Hepatic encephalopathy complicates the course of both acute and chronic liver disease and its treatment remains an unmet clinical need. Ammonia is thought to be central in its pathogenesis and remains an important target of current and future therapeutic approaches.
B M Datsenko et al.
Klinichna khirurhiia, (4)(4), 9-12 (2013-07-31)
Comparative analysis of results of examination and treatment of 54 patients, suffering obturation jaundice syndrome, is presented. The presence and severity of hepatic dysfunction was determined in accordance to indices of cytolysis and cholestasis syndromes, and its severity--in accordance to
Suzanna Ndraha et al.
Acta medica Indonesiana, 42(3), 158-161 (2010-08-21)
Excessive protein intake can cause hepatic encephalopathy (HE). Restricting protein in HE is becoming a controversy, because it can worsen malnutrition. This article reports the case of an under nourishment HE which is treated with L-ornithine-L-aspartate (LOLA) and given appropriate
Treatment of hyperammonemia in liver failure: a tale of two enzymes.
Rajiv Jalan et al.
Gastroenterology, 136(7), 2048-2051 (2009-05-05)
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